Recently widowed, Dr. Nate Samuels and his teenage daughters, Meredith and Norah, arrive on the Mopani Game Reserve in South Africa for a vacation. Nate reunites with his old friend, Martin Battles, a biologist who is a manager at Mopani. Martin takes Nate and his daughter to the village where Nate’s late wife grew up. He tells Martin that he feels guilty about the fact that he kind of distanced himself from everyone after his wife died and he wants this trip to be the way to get closer to the girls. Soon, the situation becomes dangerous when an extremely aggressive lion is discovered that has escaped from its cage and is attacking people.