Glorious after solving her first case, Enola Holmes follows in the footsteps of her famous brother, Sherlock, and opens her own agency – but soon realizes that life as a female detective is not as easy as it seems. Resigned to accept the harsh reality of adulthood, she is about to close her agency, but a girl without too much of a budget offers Enola her first official job; to find his missing sister. This case turns out to be much more twisted than expected, and Enola arrives in a new world full of dangers. From sinister London factories to colorful music studios, Enola finds herself in the middle of a deadly conspiracy and is forced to call on her friends – including her brother Sherlock – to solve this mystery.