In the near future, a virus epic seized on the planet. Dr. Lauren Chase arrives in Los Angeles along with a team of doctors to find them and help them in any possible survivors. The chances are minimal because the infected outnumber those who remained uninfected. The virus has already destroyed the entire city of New York. The only hope is to find a cure and placing the infected into quarantine. Chase moves his colleagues and Gunner Greer to a school building where a group of survivors is attacked by the infected. The two colleagues had no idea that Chase is desperate to find her husband and daughter captive somewhere in the suburbs of Los Angeles.